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新型金纳米探针研究进展

标签: 探针 Mol. 金纳米
摘要 : 目前研发安全有效的肿瘤靶向治疗的纳米探针是一项极具挑战性的任务。来自上海交通大学,安徽医科大学的研究人员研发出一种生物相容性好、靶向性好、生物安全性高的智能化的纳米探针,这种探针能准确识别活体肿瘤细胞与肿瘤中的新生血管内皮细胞,在近红外激光照射下,能选择性杀死肿瘤细胞,显著延长荷瘤小鼠的生存期。
目前研发安全有效的肿瘤靶向治疗的纳米探针是一项极具挑战性的任务。来自上海交通大学,安徽医科大学的研究人员研发出一种生物相容性好、靶向性好、生物安全性高的智能化的纳米探针,这种探针能准确识别活体肿瘤细胞与肿瘤中的新生血管内皮细胞,在近红外激光照射下,能选择性杀死肿瘤细胞,显著延长荷瘤小鼠的生存期。这一研究成果公布在《分子制药学》(molecular pharmaceutics)上。 研究组采用树形分子取代金纳米棒表面毒性分子CTAB,显著提高了金纳米棒的生物相容性,并将RGD多肽与树形分子表面基团偶联,成功构建一种新型的靶向性纳米探针。实验表明,这种新颖的智能化纳米探针能准确识别活体肿瘤细胞与肿瘤中的新生血管内皮细胞,在近红外激光照射下,能选择性杀死肿瘤细胞,显著延长荷瘤小鼠的生存期。这种智能化的纳米探针在未来的肿瘤早期探测,分子影像与靶向治疗方面具有潜在的应用价值。 原文摘要: RGD-Conjugated Dendrimer-Modified Gold Nanorods for in Vivo Tumor Targeting and Photothermal Therapy Institute for Laser Medicine & Biophotonics, School of Life sciences and Biotechnology, and National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China, Institute of Dermatology & Department of Dermatology at No. 1 Hospital, Anhui Medical University, the Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education, Hefei 230032, China, and College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China Successful development of safe and effective nanoprobes for tumor targeting and selective therapy is a challenging task. Although gold nanorods(GNRs) have the potential to perform such a role, the toxicity of surfactant cetyltrimethylammonium bromides (CTAB) on their surfaces limits their applications. Here, polyamidoamine dendrimer was applied to replace CTAB molecules on the surface of gold nanorods. When the resultant dendrimer-modified gold nanorods conjugated with arginine-glycine-aspartic acid (RGD) peptides, they showed highly selective targeting and destructive effects on the cancer cells and solid tumors under near-infrared laser irradiation. Also, we successfully observed the disappearance of tumors implanted in four sample mice from test group of ten. High-performance RGD-conjugated dendrimer-modified GNR nanoprobes exhibit great potential in applications such as tumor targeting, imaging, and selective photothermal therapy.     作者:网友 点击:
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