当前位置:生物帮 > 期刊文章 > Nature > 正文

斑马鱼单细胞脑神经活动

摘要 : 技术进步使神经科学家能够去破解行为与特定神经回路中的活动之间的关系。然而,在一个斑马鱼这样的模型体系中,还有可能在一个要大得多的尺度上去跟踪回路中的神经活动。
斑马鱼单细胞脑神经活动
技术进步使神经科学家能够去破解行为与特定神经回路中的活动之间的关系。然而,在一个斑马鱼这样的模型体系中,还有可能在一个要大得多的尺度上去跟踪回路中的神经活动。利用一个基于虚拟现实的成像系统,Florian Engert及其同事以单个神经元的分辨率对游动的鱼的适应性运动的动态进行跟踪,以寻找驱动运动学习的功能元素的候选对象。 Nature 485 (7399) | doi:10.1038/nature11057 发表日期:12年5月24日 原文摘要: Brain-wide neuronal dynamics during motor adaptation in zebrafish A fundamental question in neuroscience is how entire neural circuits generate behaviour and adapt it to changes in sensory feedback. Here we use two-photon calcium imaging to record the activity of large populations of neurons at the cellular level, throughout the brain of larval zebrafish expressing a genetically encoded calcium sensor, while the paralysed animals interact fictively with a virtual environment and rapidly adapt their motor output to changes in visual feedback. We decompose the network dynamics involved in adaptive locomotion into four types of neuronal response properties, and provide anatomical maps of the corresponding sites. A subset of these signals occurred during behavioural adjustments and are candidates for the functional elements that drive motor learning. Lesions to the inferior olive indicate a specific functional role for olivocerebellar circuitry in adaptive locomotion. This study enables the analysis of brain-wide dynamics at single-Cell resolution during behaviour. 作者:青岚 点击:
    热门文章TOP
    优发国际